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excn::tlon, and t OXICity (Am.l ET) propel1l CS has been cov· en::d ru; well.~' ~""illonl~compound VIRTUAL (IN SILl CD) SCREENING Virtual. ~nmg refen 10 lhe u:soe of computers 10 predict whcth~r D compound Will ! ity on the basis of its two-dimensional (20) or Ihree· dimensional (30) chemical ~rucl Un:: or 115 phy SICOChemical propertie~. Wc II.at1 by se'''''',nl random IInnlls of Is and Os 10 seoomc Each slrina is mea~urctl for .

excn::tlon, and t OXICity (Am.l ET) propel1l CS has been cov· en::d ru; well.~' ~""illonl~compound VIRTUAL (IN SILl CD) SCREENING Virtual. ~nmg refen 10 lhe u:soe of computers 10 predict whcth~r D compound Will ! ity on the basis of its two-dimensional (20) or Ihree· dimensional (30) chemical ~rucl Un:: or 115 phy SICOChemical propertie~. Wc II.at1 by se'''''',nl random IInnlls of Is and Os 10 seoomc Each slrina is mea~urctl for .

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hieh peptide) 01" pej)loids wcre being buill.11 Sioce chere lire 20 poss Ible amll10 accd~ and ooly foor n Ucleolidc: ~. Ilached al each ammo acid a'C pans of the s Ubstt Ule nooting In the sol ution will be t OO far from the beads 10 cause any nuorcsccncc.

Onc of the carl i CSI Iypes IIf chcmical cncoomg was the auachmenl of o Iigoouc leotides (usually IIngle'Mrdnd DNA) .n beads OIl .... the cloning and expression of mammalian receptors in microorganisms.

No put of l I1i, borofessor Emeritus Phann Jt COlogy and To Jdeology Universily or Ariz OIla Tucson, Aril Ona /. uor of Medicinal Chrmistry IIOI" composed Orttle hydrocarbon ~id C' chains of the amino l ICid~ ::0 I , , " , I R-N-M-O " " 1._.

For example, II is not Jl'O'sible 10 di~l IJ1 /l OITIlal allane$ ""th more Ihan 80 carbon ~lont S. the: energy of -80 "cal/mol required to sep;ullle the: mlecull'S is a pprm.,malc1y equal to the encrg) o,:qu ircd to bi'tak a c:ubon-carbon ro\ale:n1 bon LI.

Wilson and Gisvold's Textbook of E LEV E NTH ED I T ION Wilson and Gisvold's Textbook of ORGANIC MEDICINAL AND PHARMACEUTICAL CHEMISTRY E L E v E N T H Edited by E o I T I o N John H.

Professor of Mt.:dicinul Chemistry Department of Pharmaceutical Sciences College of Phanl1acy Oregon State Uni versity Corvallis.

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• IIOI:'b~OIt, dd K.iun, Th'$ bcg 'n~ ""II g~""l1Ilml a III; I """",ninillhe e"Urc hhnlry as I single ""'l Ure. Cllllc·· f ...,h",,, Ih~1 ali""" '" hu Ic: · roo Ic synthe!

The presence of f1l Klf"CSC1:f ICC implies that the lesl compound inhibi ted the enl.}nl C. nntage of SPA O\'er filtration is lhat no fillering of the solution is needed, so bcads can be: lidded din::ctly 10 the assay Il I.

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